NAD+ (nicotinamide adenine dinucleotide) infusion cellular therapy
Intravenous NAD+ Longevity Infusion Therapy
Industry clinical and economic procedure passport. Full biological mechanism (MoA), patient preparation protocol, first-choice equipment fleet, integration into the resort's master treatment rooms and market price benchmarks.
Clinical profile
Intravenous NAD⁺ is a popular "cellular recovery" procedure in wellness clinics. Oral NAD⁺ precursors (NR, NMN) reliably raise NAD⁺ levels and are well tolerated, but for intravenous NAD⁺ for anti-ageing or wellness there are no clinical outcome studies; 2026 reviews call the evidence preliminary.
Every statement links to a publication in the list below. This is a snapshot of published research, not a final assessment of the method: international practice and integrated protocols often run ahead of official publications. Draft based on published research; requires review by a physician. Revision: 2026-10-17.
Mechanism of action
- NAD⁺ levels decline with age, which is the rationale for repletion strategies. [1]
- During intravenous infusion (3 µmol/min), NAD⁺ is cleared from plasma rapidly and completely in the first 2 hours; metabolites point to enzymatic breakdown. [4]
- The response to NAD⁺ is non-linear: it depends on dose, age, metabolism and route of administration, with feedback and saturation. [3]
Where studies show an effect
- Heart failure in ischaemic cardiomyopathy: in an RCT (180 patients), 7 days of IV NAD⁺ added to standard therapy improved cardiac function. [5]
- Oral precursors raise NAD⁺ and are safe; individual RCTs showed increased muscle insulin sensitivity in women with prediabetes and aerobic endurance in runners. [6, 8, 9]
Open questions and study limitations
- No clinical studies of intravenous or intramuscular NAD⁺ for anti-ageing and wellness have been published yet. [1, 2]
- In humans, the effects of precursors on functional, metabolic and vascular measures are inconsistent and often absent. [1]
- The optimal dose, duration of effect and long-term safety of intravenous NAD⁺ have not been established. [2]
Protocol in studies
Equipment fleet and fit-out
Certified first-choice medical equipment and compatible device systems
Device platform with proven validation of the biological response. Includes built-in biofeedback sensor systems, patient protection protocols and precision dosing of exposure.
Architectural integration and treatment rooms
Resort rooms housing the treatment station (with SanPiN norms and MEP loads)
Unit economics and resort price benchmarks
Market analysis based on a sample of premium sanatoriums, wellness hotels and preventive medicine clinics
Median of prices in industry facilities' price lists, 2026
Prices for this procedure appear in the price lists of 1 industry facilities; the median and interquartile range across facilities are shown (each facility counts once).
Evidence base
For intravenous NAD⁺ for wellness purposes there are no clinical outcome studies; there is one RCT in heart failure and RCTs of oral precursors with mixed results.
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1.
NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence.Ageing Res Rev, 2026 · Systematic review (PRISMA) · PMID 41655607113 studies: in humans precursors raise NAD⁺, but clinical effects are inconsistent; there are no outcome studies of intravenous NAD⁺ for anti-ageing.
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2.
Narrative review of intravenous NAD+ and NAD+ precursors in wellness and translational medicine.Front Aging, 2026 · Review · PMID 42787547Data on intravenous NAD⁺ are preliminary and insufficient for routine clinical or wellness use.
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3.
NAD⁺ biology and supplementation: From mechanisms to clinical perspectives.Mol Biol Rep, 2026 · Review · PMID 42489969The response to NAD⁺ is non-linear and depends on dose, age, metabolic state and route of administration.
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4.
A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD.Front Aging Neurosci, 2019 · Pilot pharmacokinetic study · PMID 31572171During infusion NAD⁺ disappears rapidly from plasma; it is excreted in urine as NAD⁺ and methylnicotinamide.
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5.
Effect of Nicotinamide Adenine Dinucleotide on Heart Failure Caused by Ischemic Cardiomyopathy: A Randomized, Placebo-Controlled Trial.Am J Cardiovasc Drugs, 2026 · RCT, placebo-controlled · PMID 40954388180 patients with ischaemic cardiomyopathy: 7 days of IV NAD⁺ improved cardiac function; a trend towards lower NT-proBNP and fewer hospitalisations.
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6.
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults.Nat Commun, 2018 · RCT · PMID 29599478Nicotinamide riboside is well tolerated and raises NAD⁺ in healthy middle-aged and older people.
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7.
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.Geroscience, 2023 · RCT, multicentre · PMID 36482258NMN up to 900 mg a day is safe and raises blood NAD⁺; the best effect is at 600 mg.
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8.
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.Science, 2021 · RCT · PMID 33888596NMN increased muscle insulin sensitivity in overweight women with prediabetes.
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9.
Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study.J Int Soc Sports Nutr, 2021 · RCT · PMID 34238308NMN improved aerobic capacity in recreational runners.
Publications were found in PubMed; titles and journals are given verbatim, conclusions are a brief summary of the abstracts under the conditions of the specific studies. The level shows the volume of published data, not the value of the method: A — Plenty of data: consistent systematic reviews and meta-analyses of RCTs; B — Some data: reviews or several RCTs, results are heterogeneous; C — Little data: single RCTs or controlled studies; D — Scarce data: mainly reviews, observational and experimental studies. The passport is updated as new work is published and with regard to international practice.