MEDISPA.PRO
Ministry of Health code: — Axis M3 · Mitochondrial health and energy metabolism CEBM: Level C (Gas inhalation therapy)

Molecular hydrogen inhalation (hydrogen-oxygen mixture)

Molecular Hydrogen Inhalation

Industry clinical and economic procedure passport. Full biological mechanism (MoA), patient preparation protocol, first-choice equipment fleet, integration into the resort's master treatment rooms and market price benchmarks.

To the procedure catalogue Equipment fleet Integration treatment rooms Rates and economics
Session duration
40 min
Turnover: ~55 min
Recommended course
10 sessions
10 treatments – an assumption for the economic calculation; the course is prescribed by a physician
Throughput capacity
9 pts
per 8-hour shift
Median rate
2 500 ₽
1 960 ₽ – 6 150 ₽
Course cost
25 000 ₽
at market median
Publication volume
Level C
6 publ. in PubMed

Clinical profile

Inhalation of hydrogen (usually mixed with oxygen). In experiments, hydrogen shows antioxidant and anti-inflammatory properties; clinically there are a few small RCTs (fatty liver disease, athletes) and no large trials. Most reviews concern hydrogen water rather than inhalation.

Every statement links to a publication in the list below. This is a snapshot of published research, not a final assessment of the method: international practice and integrated protocols often run ahead of official publications. Draft based on published research; requires review by a physician. Revision: 2026-10-17.

Mechanism of action

  • In basic research, hydrogen has antioxidant, anti-inflammatory and anti-apoptotic effects and protects mitochondria. [1]
  • In preclinical models, hydrogen improved outcomes in sepsis, acute lung, liver and kidney injury, trauma and brain injury. [2]

Where studies show an effect

  • Moderate to severe non-alcoholic fatty liver disease: improvement in a placebo-controlled RCT. [3]
  • Intensive training: professional rugby players showed fewer markers of inflammation and oxidative stress. [4]
  • Physical performance in healthy people: possible gains in explosive power and less fatigue (the review mainly covers oral intake). [5]

Open questions and study limitations

  • Preventive and therapeutic benefit in nervous system disorders remains uncertain owing to the lack of large RCTs. [1]
  • No effect on aerobic and anaerobic endurance or muscle strength was found in the meta-analysis. [5]
  • Hydrogen water needs studies with large samples and rigorous methodology. [6]

Safety

  • In humans with various diseases, hydrogen showed a good safety profile. [2]
Contraindications. Contraindications are determined by the physician according to the equipment or drug instructions; they are not given in study abstracts.

Equipment fleet and fit-out

Certified first-choice medical equipment and compatible device systems

Equipment registry
Base configuration (Hero Device)
Hydrogen-oxygen gas generator

Device platform with proven validation of the biological response. Includes built-in biofeedback sensor systems, patient protection protocols and precision dosing of exposure.

Certification: Russian Ministry of Health registration certificate / CE Medical Device Directive Class IIa/IIb.
Compatible platforms in the MEDISPA.PRO registry
EMW H5250 hydrogen and oxygen generator
Medical device, Roszdravnadzor registration certificate / CE
In the registry →

Architectural integration and treatment rooms

Resort rooms housing the treatment station (with SanPiN norms and MEP loads)

All treatment rooms →
1.3.1 120.0 m² · Class B

Treatment room for intravenous infusions / treatment room / laser blood irradiation / ozone therapy room / blood UV irradiation (10 individual cubicles)

General therapeutic interventions and high-tech therapy · Equipment: 11 538 900 ₽

Treatment room passport →
1.3.5 30.0 m² · Class B

Gas inhalation therapy room

General therapeutic interventions and high-tech therapy · Equipment: 11 976 600 ₽

Treatment room passport →

Unit economics and resort price benchmarks

Market analysis based on a sample of premium sanatoriums, wellness hotels and preventive medicine clinics

Market price corridor
25th percentile (P25) 1 960 ₽
Market median 2 500 ₽
75th percentile (P75) 6 150 ₽

Median of prices in industry facilities' price lists, 2026

Basis of the price benchmark

Prices for this procedure appear in the price lists of 3 industry facilities; the median and interquartile range across facilities are shown (each facility counts once).

Evidence base

There are isolated small RCTs with inhalation; systematic reviews note a lack of large trials.

Publication level C · Little data
  1. 1.
    Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application.
    Curr Opin Anaesthesiol, 2020 · Systematic review · PMID 32826628
    Antioxidant and anti-inflammatory effects in basic research; large RCTs are needed for clinical conclusions.
  2. 2.
    Gas as medicine: the case for hydrogen gas as a therapeutic agent for critical illness.
    Intensive Care Med Exp, 2025 · Review · PMID 40938520
    In preclinical studies, hydrogen improved outcomes in sepsis and in lung, liver, kidney and brain injury; in humans it has a good safety profile.
  3. 3.
    A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic fatty liver disease.
    J Cell Mol Med, 2022 · RCT (placebo-controlled) · PMID 35734974
    Inhalation of a hydrogen-oxygen mixture reduced the manifestations of moderate to severe non-alcoholic fatty liver disease.
  4. 4.
    Hydrogen gas inhalation prior to high-intensity training reduces attenuation of nitric oxide bioavailability in male rugby players.
    PeerJ, 2024 · RCT · PMID 39703911
    In rugby players, inhalation before training maintained NO bioavailability and reduced markers of inflammation and oxidative stress.
  5. 5.
    Can molecular hydrogen supplementation enhance physical performance in healthy adults? A systematic review and meta-analysis.
    Front Nutr, 2024 · Systematic review and meta-analysis · PMID 38903627
    In healthy adults, hydrogen improved explosive power and reduced fatigue, but not endurance or strength.
  6. 6.
    Hydrogen Water: Extra Healthy or a Hoax?-A Systematic Review.
    Int J Mol Sci, 2024 · Systematic review · PMID 38256045
    Hydrogen water: preliminary results are encouraging; large studies of rigorous design are needed.

Publications were found in PubMed; titles and journals are given verbatim, conclusions are a brief summary of the abstracts under the conditions of the specific studies. The level shows the volume of published data, not the value of the method: A — Plenty of data: consistent systematic reviews and meta-analyses of RCTs; B — Some data: reviews or several RCTs, results are heterogeneous; C — Little data: single RCTs or controlled studies; D — Scarce data: mainly reviews, observational and experimental studies. The passport is updated as new work is published and with regard to international practice.