MEDISPA.PRO
Ministry of Health code: A20.30.024.006 Axis M6 · Immunity and systemic inflammation CEBM: Level C (Blood purification and detoxification)

Systemic ozone therapy (IV ozonated solution, major autohaemotherapy)

Systemic Ozone Therapy

Industry clinical and economic procedure passport. Full biological mechanism (MoA), patient preparation protocol, first-choice equipment fleet, integration into the resort's master treatment rooms and market price benchmarks.

To the procedure catalogue Equipment fleet Integration treatment rooms Rates and economics
Session duration
40 min
Turnover: ~55 min
Recommended course
8 sessions
8 treatments – an assumption for the economic calculation; the course is prescribed by a physician
Throughput capacity
9 pts
per 8-hour shift
Median rate
1 750 ₽
1 450 ₽ – 3 088 ₽
Course cost
14 000 ₽
at market median
Publication volume
Level C
7 publ. in PubMed

Clinical profile

Introducing ozone into the body via the blood — a drip of ozonated saline or major autohaemotherapy. Reviews describe analgesic and anti-inflammatory effects; clinical data come from small low-quality studies, and results in COVID-19 are conflicting. Few studies specifically on ozonated saline drips are in PubMed.

Every statement links to a publication in the list below. This is a snapshot of published research, not a final assessment of the method: international practice and integrated protocols often run ahead of official publications. Draft based on published research; requires review by a physician. Revision: 2026-10-17.

Mechanism of action

  • Ozone-oxygen therapy is credited with analgesic, anti-inflammatory, antioxidant and immunomodulatory effects. [1]

Where studies show an effect

  • Post-herpetic neuralgia: ozone autohaemotherapy combined with drugs is more effective than drugs alone. [2]
  • Diabetic foot syndrome: ozone therapy as part of treatment speeds healing and reduces the amputation rate. [5]

Open questions and study limitations

  • COVID-19: two meta-analyses contradict each other — from reduced mortality to improvement in laboratory parameters only. [3, 4]
  • In diabetic foot, the proportion of complete healing does not differ from standard treatment. [5]

Safety

  • Complications of ozone therapy, usually minor but potentially serious, are under-reported in studies. [6]
  • No adverse events were described in the chronic wounds review. [7]
Contraindications. Contraindications are determined by the physician according to the equipment or drug instructions; they are not given in study abstracts.

Equipment fleet and fit-out

Certified first-choice medical equipment and compatible device systems

Equipment registry
Base configuration (Hero Device)
Medical ozone generator

Device platform with proven validation of the biological response. Includes built-in biofeedback sensor systems, patient protection protocols and precision dosing of exposure.

Certification: Russian Ministry of Health registration certificate / CE Medical Device Directive Class IIa/IIb.
Compatible platforms in the MEDISPA.PRO registry
Medozon ozone therapy device with accessories: Hyper Medozon Comfort ozone therapy device
Medical device, Roszdravnadzor registration certificate / CE
In the registry →

Architectural integration and treatment rooms

Resort rooms housing the treatment station (with SanPiN norms and MEP loads)

All treatment rooms →
1.3.1 120.0 m² · Class B

Treatment room for intravenous infusions / treatment room / laser blood irradiation / ozone therapy room / blood UV irradiation (10 individual cubicles)

General therapeutic interventions and high-tech therapy · Equipment: 11 538 900 ₽

Treatment room passport →

Unit economics and resort price benchmarks

Market analysis based on a sample of premium sanatoriums, wellness hotels and preventive medicine clinics

Market price corridor
25th percentile (P25) 1 450 ₽
Market median 1 750 ₽
75th percentile (P75) 3 088 ₽

Median of prices in industry facilities' price lists, 2026

Basis of the price benchmark

Prices for this procedure appear in the price lists of 8 industry facilities; the median and interquartile range across facilities are shown (each facility counts once).

Evidence base

There are meta-analyses of small low-quality studies with conflicting conclusions; data specifically on intravenous drips are scarce.

Publication level C · Little data
  1. 1.
    Ultrasonography for oxygen-ozone therapy in musculoskeletal diseases.
    Med Gas Res, 2019 · Review · PMID 30950416
    Ozone-oxygen therapy is credited with analgesic, anti-inflammatory, antioxidant and immunomodulatory effects.
  2. 2.
    The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia.
    J Pain Res, 2018 · Clinical study · PMID 30214273
    Post-herpetic neuralgia: autohaemotherapy with ozone combined with drugs is better than drugs alone.
  3. 3.
    Benefits of ozone on mortality in patients with COVID-19: A systematic review and meta-analysis.
    Complement Ther Med, 2023 · Systematic review and meta-analysis · PMID 36513208
    COVID-19: in the meta-analysis, reduced mortality, PCR positivity and length of hospital stay.
  4. 4.
    Ozone as an adjuvant therapy for COVID-19: A systematic review and meta-analysis.
    Int Immunopharmacol, 2022 · Systematic review and meta-analysis · PMID 35803132
    COVID-19: only laboratory markers improved in severely ill patients; mortality and hospitalisation did not.
  5. 5.
    Effect of Ozone Therapy on Diabetes-related Foot Ulcer Outcomes: A Systematic Review and Meta-analysis.
    Curr Pharm Des, 2024 · Systematic review and meta-analysis · PMID 38982924
    Diabetic foot: faster healing and fewer amputations, but complete healing as with standard treatment.
  6. 6.
    Ozone therapy for low back pain. A systematic review.
    Acta Reumatol Port, 2018 · Systematic review · PMID 30414366
    Few studies, of low quality; complications, usually minor but potentially serious, are under-reported.
  7. 7.
    A systematic review of ozone therapy for treating chronically refractory wounds and ulcers.
    Int Wound J, 2022 · Systematic review · PMID 34612569
    Chronic wounds: no adverse events of ozone therapy described; high-quality RCTs are needed.

Publications were found in PubMed; titles and journals are given verbatim, conclusions are a brief summary of the abstracts under the conditions of the specific studies. The level shows the volume of published data, not the value of the method: A — Plenty of data: consistent systematic reviews and meta-analyses of RCTs; B — Some data: reviews or several RCTs, results are heterogeneous; C — Little data: single RCTs or controlled studies; D — Scarce data: mainly reviews, observational and experimental studies. The passport is updated as new work is published and with regard to international practice.